5 basic questions about triacetin: production, application, safety, purchase, etc

What is triacetin?

The compound of triacetin has a molecular formula of C9H14O6. Colorless oily liquid. It can be miscible with ethanol; ether; chloroform and benzene, slightly soluble in water and carbon disulfide. Suffering. Used as a perfume fixative, solvent, toughener. Used in the production of cosmetics, medicines and dyes, as a plasticizer for cigarette filter rods, etc.

Name Triacetin
Another name 1,2,3-Propanetriol triacetate; Glycerol Triacetate, USP Grade(1.03000); TRIACETINE; Glycerol triacetate; Glyceryl triacetate
CAS No 102-76-1
Molecular formula C9H14O6
Melting point 3℃
Relative density 1.155
Water solubility 64.0 g/L (20℃)

How to make triacetin

  1. It is obtained by esterification of acetic anhydride with hot glycerol and purification by vacuum distillation.
  2. Esterification from glycerol and acetic acid: After preheating glycerin to 50-60 ° C, acetic acid, benzene and sulfuric acid are added. The mixture was heated and stirred to reflux and dehydrated. After dehydration, benzene was recovered, and then acetic anhydride was added thereto, followed by heating for 4 hours. After cooling, the pH was neutralized to 7% with 5% sodium carbonate, and the aqueous layer was separated, and the crude oil was dried over calcium chloride. Distillation under reduced pressure, collecting 128-131 ° C (0.93 kPa) fraction, which is triacetin.
  3. Esterification reaction: A certain amount of glycerin, glacial acetic acid (molar ratio of alcohol: 1:4), a supported heteropolyacid catalyst (2.5% of the mass of the alcohol) and a toluene with a water agent were added to the column. The temperature adjusting agent) heats the liquid in the column to make the liquid in a slightly boiling or boiling state, and performs a reactive distillation operation. The ester phase in the overhead trap is returned to the rectification column and the aqueous phase is produced. When there is no water drop in the top water separator, a certain amount of acetic anhydride is added to the tower kettle, and after 4 hours, the esterification reaction is terminated, and after cooling, the crude ester is obtained; (CH2OH)2CHOH+3CH3COOH→(Cat) ., Benzene) (CH2OCOCH3) 2 CHOCOCH3 crude ester purification: The crude ester was cooled, and the solid catalyst filtrate was filtered. First, atmospheric distillation is carried out to recover excess glacial acetic acid and water-containing toluene. When the distillate is rare, it is changed to vacuum distillation, further removing glacial acetic acid, and controlling the temperature of the kettle liquid to be within 100-120 ° C. When the distillate is stopped, the distillation operation is stopped; the temperature of the kettle liquid is lowered to 100 ° C, a certain amount of decolorizing agent activated carbon is added, and after stirring for a certain period of time, it is cooled, and the decolorizing agent is filtered off to obtain a product of triacetin.

Application of triacetin


Triacetin liquid Industry grade applications

1.Used as core sand binder in metal foundry sector.

2.Used as solvent in printing inks.

3.Used as a highly effective plasticizer for cellulose-based plastics.

4.Used as solvent in building wall coating

Food grade

Triacetin liquid food grade applications:

Triacetin liquid in Food Production

Triacetin is widely used as humectant, emlusifier, binder in food production.

As plasticizer: in gum to plasticize.

As leavening agents: in baked food to promote fermentation.

As emulsifier: in dairy product to promote emulsification.

triacetin used in cigarettes filter

Triacetin liquid in Beverage

Triacetin is widely used as emulsifier, flavor enhancer in beverage.

As emulsifier, flavor enhancer: in beverage industries to enhance flavor and promote emulsification.

Pharmaceutical grade

Triacetin liquid in Pharmaceutical

Triacetin is widely used as Antifungal agents, plasticizers in Pharmaceutical.

As Antifungal agents: in drugs to inhibit fungus.

As plasticizer: in capsule shell to plastify.

Cosmetics grade

Triacetin liquid in Cosmetics

Triacetin is widely used as humectant, plasticizer in Cosmetics.

As humectant, plasticizer: in cosmetic to maintain moisture.

As plasticizer: in nail polish to plastify.

Feed grade

Triacetin liquid in Agriculture/Animal Feed

Not enough is known about application of Triacetin in Agriculture/Animal Feed.

Triacetin liquid in Other Industries

Triacetin is widely used as binder in various other industries.

As binder: in cigarette filters to plasticize and solidify.

For example, triacetate is used in cigarette filters

Most of the filters used in cigarettes are made of cellulose acetate, which is also a plastic used to produce photographic film. Thousands of acetate fibers are compressed together to form a filter, and the fibers are bonded together with a substance called triacetin. After processing, the filter looks like cotton.

About safety, toxicity and side effects of triacetin

Health hazards: May be irritating. It is generally believed that there are no health problems in food and industrial exposure.

Environmental hazards: Harmful to the environment.

Explosion hazard: This product is flammable.

Skin contact: Remove contaminated clothing and rinse with running water.
Eye contact: Lift eyelids and rinse with running water or saline. Seek medical attention.
Inhalation: Remove quickly from the scene to fresh air. Keep the airway open. If breathing is difficult, give oxygen. If breathing stops, perform artificial respiration immediately. Seek medical attention.
Ingestion: Drink plenty of warm water and induce vomiting. Seek medical attention.

Fire-fighting measures

Hazardous characteristics: In case of high heat, open flame or contact with oxidizing agents, there is a danger of burning.

Hazardous combustion products: carbon monoxide, carbon dioxide.

Extinguishing method: Move the container from the fire to the open space as much as possible. Spray water to keep the fire container cool until the end of the fire. If the container in the fire has changed color or produces sound from a safety relief device, it must be evacuated immediately. Extinguishing media: water spray, foam, dry powder, carbon dioxide, sand.

Leakage emergency treatment

Emergency treatment: quickly evacuate people from the contaminated area to a safe area, and conduct isolation and strictly restrict access. Cut off the fire. It is recommended that emergency personnel wear self-contained breathing apparatus and wear general work clothes. Do not touch the spill directly. Cut off the source of the leak as much as possible. Prevent entry into restricted spaces such as sewers and flood drains. Small spill: Absorb with sand, vermiculite or other inert materials. A large number of leaks: building dikes or digging pits. Transfer to a tank truck or special collector with a pump, recycle or transport to a waste disposal site for disposal.

Contact control / personal protection

Engineering control: The production process is closed and fully ventilated.

Respiratory protection: generally does not require special protection, self-priming filter gas mask (half mask) can be worn when exposed to high concentrations.

Eye protection: Wear chemical safety glasses when the air concentration is high.

Body protection: Wear anti-static overalls.

Hand protection: Wear chemical resistant gloves.

Other protection: Do not eat, drink or smoke while working. Work is done and thoroughly cleaned. Maintain good hygiene practices.

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